Periconception in Physiology and Medicine

I. General Introduction.- 1. Defining the events taking place during the periconception period.- 2. The importance of immediate effects of the periconception period in reproductive medicine and human assisted reproduction.- 3. The importance of immediate effects of periconception period in animal breeding and biotechnological advances such as artificial insemination (AI) and embryo transfer (ET).- II. Establishment of Periconception Environment.- 4. The consequences of molecular cross-talk between maternal tract, gametes and embryo taking place during the periconception period.- 5. The consequences of molecular cross-talk taking place during periconception period on embryo development.- 6. What are signalling mechanisms that convey information between gametes, embryo and the maternal tract?.- III. Long-term Effect of Periconception.- 7. The long-term effects of the periconception period on the embryo's epigenetic profile and phenotype: the role of nutrition.- 8. The long-term effect of the periconception period on the embryo's epigenetic profile and phenotype: the role of smoking and alcohol.- 9. The long-term effects of the periconception period on embryo epigenetic profile and phenotype: the role of infection and allergens.- 10. The long-term effects of the periconception period on embryo epigenetic profile and phenotype: the role of environmental pollution and toxins.- 11. Experimental animal models.- 12. Conclusions

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• Medicina reproductiva
• Fisiologia
• Biologia do desenvolvimento