Studies on Experimental Toxicology and Pharmacology

Studies on Experimental Toxicology and Pharmacology

Kehrer, James P.; Klotz, Lars-Oliver; Roberts, Stephen M.

Birkhauser Verlag AG

08/2016

498

Mole

Inglês

9783319347080

15 a 20 dias

This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research.
Part I. Toxicological Mechanisms and Evaluation of Oxidative Stress.- A historical perspective on oxidative stress and intracellular redox control .- An overview of free radicals as causes and consequences of toxicity.- Oxidants, radicals, free radicals, and other bad stuff in mechanisms of toxicity.- Lipid oxidation.- Protein oxidation and toxicology.- Oxidative stress and DNA damage association with carcinogenesis: A truth or a myth?.- Glutathione and thiols .- Reactive oxygen species as initiators and mediators of cellular signaling processes.- Role of oxidative stress in the process of carcinogenesis.- Part II. Agents that produce toxicity - mechanisms and therapeutic interventions.- Isolation of murine adult bone marrow and fetal liver cells for mechanistic assessment of hematotoxicity caused by organic solvents.- Oxidative stress and ethanol toxicity.- Pharmaceutical agents.- Insecticides and herbicides .- Health effects of indoor air pollution due to cooking with biomass fuel.- Outdoor pollutants.- Oxidative Stress and the Inorganic Carcinogens.- UV-induced signaling: Role of reactive oxygen species.- Nanomaterials.- Chemical warfare agents.- Part III. Special topics.- On the biochemistry of antioxidants - current aspects.-Prevention of age-related diseases - Effects of antioxidant supplements.- The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity - a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging..- Oxygen toxicity: From cough to convulsion.- Oxidative stress in reproductive toxicology.- Toxicogenomics-based assessment of xenobiotic-induced oxidative stress.- Aquatic and marine biology.
Este título pertence ao(s) assunto(s) indicados(s). Para ver outros títulos clique no assunto desejado.