Free Fatty Acid Receptors

Free Fatty Acid Receptors

Kimura, Ikuo; Milligan, Graeme

Springer International Publishing AG

07/2018

256

Mole

Inglês

9783319844640

15 a 20 dias

551

Descrição não disponível.

Ligands at Free Fatty Acid Receptor 1 (GPR40).- Ligands at Free Fatty Acid Receptor 2/3 (GPR43)/GPR41.- Ligands at GPR84.- Ligands at Free Fatty Acid Receptor 4 (GPR120).- Homology modelling of FFA receptors.- Sensors for FFA receptors.- Key questions for translation of FFA receptors from pharmacology to medicines.- Polymorphic variation in FFA receptors. Functions and consequences.- The role and future of FFA1 as a therapeutic target.- Gut hormone regulation and secretion via FFA1 and FFA4.- The role of FFA2 and FFA3 in metabolic regulation.- Anti-inflammatory and insulin sensitizing effects of free fatty acid receptors.- Free Fatty Acid receptors and cancer.

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Receptors for Free Fatty Acids;Diabetes;Inflammation;Ligand function;Homology modelling;Systems Biology