Precision Medicine, CRISPR, and Genome Engineering

Precision Medicine, CRISPR, and Genome Engineering

Moving from Association to Biology and Therapeutics

Church, George M.; Tsang, Stephen H.

Springer International Publishing AG

09/2018

178

Mole

Inglês

9783319876672

15 a 20 dias

454

Descrição não disponível.
Part 1. Introduction to the CRISPR Revolution.- 1. Viral Vectors, Engineered Cells and the CRISPR Revolution.- 2. Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing.- Part 2. CRISPR in Model Systems.- 3. From Reductionism to Holism: Toward a More Complete View of Development through Genome Engineering.- 4. Genome Engineering in Mice.- 5. Genome Editing to Study Ca2+ Homeostasis in Zebrafish Cone Photoreceptors.- 6. From Prokaryotic Immune Systems to Plant Genome Editing Tools.- 7. Part 3. The Future of CRISPR.- 7. Using High-throughput Gene Editing to Identify Therapeutic Targets in the Noncoding Genome.- 8. CRISPR in the Retina: Evaluation of Future Potential.- 9. The Future of CRISPR Applications in the Lab, the Clinic and Society.
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Genetically Modified;gRNA Design;Ophthalmologic Disease;ZFN;TALEN